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According to People, Olivia's father, Brinley Newton-John, died of cancer a mere fortnight before her 1992 diagnosis.
In 2013, Olivia's sister Rona lost her battle with brain cancer - her death tragically falling on the same day as their mother's birthday, the publication reported.
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Known for her philanthropic spirit and bubbly demeanor during media appearances, Olivia's health crisis is just the latest in a string of tragic events for which the singer has put a brave face forward.
Olivia first faced the illness in 1992, diagnosed with breast cancer aged 43.
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On Tuesday, 25 years after she was first diagnosed, Olivia confirmed she was battling breast cancer for the second time with the illness also spreading to her sacrum.